Çocuk Sağlığı ve Hastalıkları Dergisi 2007 , Vol 50 , Num 2
Frequency of reflux esophagitis in celiac disease
Murat Çakır1, Gökhan Tümgör1, Hasan Ali Yüksekkaya1, Semiha Terlemez2 Raşit Vural Yağcı3, Sema Aydoğdu3
1Ege Üniversitesi Tıp Fakültesi Pediatri Uzmanı,
2Ege Üniversitesi Tıp Fakültesi Pediatri Araştırma Görevlisi
3Ege Üniversitesi Tıp Fakültesi Pediatri Profesörü
Çakır M, Tümgör G, Yüksekkaya HA, Terlemez S, Yağcı RV, Aydoğdu S. (Department of Pediatrics, Ege University Faculty of Medicine, İzmir, Turkey). Frequency of reflux esophagitis in celiac disease. Çocuk Sağlığı ve Hastalıkları Dergisi 2007; 50: 91-95.

Gastrointestinal motor abnormalities, such as decrease in lower eosophageal sphincter pressure, have been defined in patients with celiac disease. Hence, these patients have risk for reflux esophagitis. In this study, we evaluate the frequency of reflux esophagitis and reflux symptoms in pediatric patients with newly diagnosed celiac disease. The study consisted of 71 patients with celiac disease and 292 children who underwent upper gastrointestinal endoscopy due to chronic abdominal pain, vomiting or gastrointestinal bleeding at the time of the study. Nineteen celiac patients (26.7%) and 34 patients (11.6%) in the control group had reflux esophagitis in the histopathological examination of distal esophageal biopsies (p<0.001). Symptoms such as vomiting, nausea, and dysphagia were more common in celiac patients with reflux oesophagitis (p<0.05 for nausea). No significant difference was found in terms of histopathological grade in celiac patients with and without reflux esophagitis. Patients with reflux esophagitis had lower ferritin levels than the others (4.6±3.5 μg/dl, 10.1±12.9 μg/dl; p<0.05). Iron deficiency anemia was more common in patients with reflux esophagitis, but the difference was not significant. Symptoms related with reflux improved after gluten-free diet within six months in all cases. In this study, we revealed that the frequency of reflux esophagitis is increased in patients with celiac disease. We conclude that further immunohistochemical and morphometric studies will clarify the pathogenesis of esophageal damage in patients with celiac disease. Anahtar Kelimeler : çölyak hastalığı, çocuklar, reflü ösefajit, celiac disease, children, reflux esophagitis

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