Çocuk Sağlığı ve Hastalıkları Dergisi
2010 , Vol 53 , Num 1
Dubin-Johnson and Rotor syndromes:report of three cases
Hacettepe Üniversitesi Tıp Fakültesi 1Pediatri Uzmanı, 2Pediatri Araştırma Görevlisi, 3Pediatri Yardımcısı Doçenti,
4Pediatri Profesörü, 5Pediatri Doçenti
Dubin-Johnson and Rotor syndromes are rare, benign, hereditary chronic
disorders characterized by conjugated hyperbilirubinemia. In Dubin-Johnson
syndrome, deposition of melanin-like pigment in otherwise normal liver cells and
in some cases hepatomegaly and abdominal pain are observed. Both syndromes
show no abnormality in other liver function tests, and patients with these
syndromes are otherwise healthy. Differential diagnosis of these diseases must
be considered in patients with slightly elevated conjugated hyperbilirubinemia
and normal liver functions. Three cases of Dubin-Johnson and Rotor syndrome
are reported herein, and the differential diagnosis is discussed.
Anahtar Kelimeler :
Sarılık, Dubin-Johnson sendromu, Rotor sendromu.