Çocuk Sağlığı ve Hastalıkları Dergisi
2013 , Vol 56 , Num 3
The role of Th17 and Treg cells on development of glomerulonephritis
Hacettepe Üniversitesi Tıp Fakültesi 1Pediatrik Nefroloji Uzmanı, 2Pediatri Profesörü *İletişim: sezaozen@hacettepe.edu.tr
T helper (Th) cells play important roles in the development of autoimmune
diseases. Studies related to the role of emerging Th subsets in the development
of glomerulonephritis have increased in recent years. Description of new Th
subsets leads to a better understanding of the disease-causing mechanisms
and pathogenesis of glomerulonephritis. Findings of the studies related to
the subject are extremely important for delineation of different aspects of
renal injury mechanisms. The definition of the relation of these mechanisms
with clinical parameters and disease prognosis may help in developing new
management strategies. In addition, different aspects of renal inflammation may
lead to the development of new treatment modalities in addition to classical
immunosuppressive drugs. These may result in increased patient survival and
quality of life. This study aimed to summarize the data regarding the role
of Th17 and Treg in the development of glomerulonephritis.
Anahtar Kelimeler :
yardımcı T hücreleri, düzenleyici T hücreleri, glomerülonefrit.