Çocuk Sağlığı ve Hastalıkları Dergisi
2014 , Vol 57 , Num 1
Iatrogenic Cushing syndrome due to topical corticosteroid in an infant with ichthyosis: a case report
Bezmiâlem Vakıf Üniversitesi 1Pediatri Uzmanı, 2Pediatri Yardımcı Doçenti, Bakırköy Sadi Konuk Eğitim ve Araştırma
Hastanesi 3Klinik Biyokimya Uzmanı, İstanbul Eğitim ve Araştırma Hastanesi 4Çocuk Cerrahisi Uzmanı
*İletişim: ayvahap@hotmail.com
Topical corticosteroids are one of the oldest and most frequently used
treatments for dermatologic conditions. Corticosteroids are absorbed easily
through the skin, and this may lead to a varying degree of suppression of
the hypothalamic-pituitary-adrenal axis. Herein, we report a seven-month-old
female infant with ichthyosis who developed iatrogenic Cushing's syndrome
after diaper dermatitis treatment involving the extensive misuse of topical
diflucortolone valerate prescribed by the physician. We also discuss the effects
of topical steroids on the adrenal axis. The body surface area in children is
so large in comparison to the body mass, and their skin is thin; hence, they
may readily suffer the systemic side effects of the percutaneous absorption of
corticosteroids. Awareness of the side effects is important when prescribing
steroid-containing medication, especially during childhood.
Anahtar Kelimeler :
kortikosteroidler, iatrojenik Cushing sendromu, iktiyozis, süt
çocukluğu.