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Ege Üniversitesi Tıp Fakültesi ¹Pediatri Uzmanı, ³Pediatri Profesörü, Sosyal Sigortalar Kurumu İzmir Tepecik Eğitim Hastanesi ²Pediatri Doçenti Juvenile ankylosing spondylitis and inflammatory bowel disease rarely develop simultaneously, and the treatment of the disease with disease-modifying antirheumatic drugs might be difficult. In this report we present an eight-year old boy with juvenile ankylosing spondylitis and inflammatory bowel disease resistant to combined therapy of antirheumatismal drugs because of its rarity in childhood. Anti-tumor necrosis factor-a monoclonal antibody administration, a new biological treatment, is discussed in view of the literature. Anahtar Kelimeler : juvenil ankilozan spondilit, inflamatuvar barsak hastalığı, anti-TNF-a monoklonal antikor, juvenile ankylosing spondylitis, inflammatory bowel disease, Anti-tumor necrosis factor-a monoclonal antibody