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Erciyes Üniversitesi Tıp Fakültesi ¹Pediatri Profesörü, ²Pediatri Araştırma Görevlisi, ³Pediatri Yardımcı Doçenti Melkersson-Rosenthal syndrome is a rare disorder consisting of the triad of persistent or recurrent orofacial edema, relapsing peripheral facial paralysis and fissured tongue. The etiology of the disorder is unknown; a possible association with sarcoidosis and Crohn's disease has been proposed. Therapeutic options for Melkersson-Rosenthal syndrome in childhood are limited (oral prednisolone, clofazimine and minocycline). We present two cases of Melkersson-Rosenthal syndrome with the classic triad of symptoms. Our patients were successfully treated with a 4-week course of prednisolone (1 mg/kg/day). We report these cases because this syndrome is very rare in childhood, and oral prednisolone is effective in the treatment. Anahtar Kelimeler : Melkersson-Rosenthal sendromu, fasiyal paralizi, Melkersson-Rosenthal syndrome, facial paralysis