Çocuk Sağlığı ve Hastalıkları Dergisi 2003 , Vol 46 , Num 1
Comparison of proton pump inhibitor versus H2 receptor blocker based triple therapy protocols for eradication of H. pylori infection in children
Özlem D. Süoğlu1, Berna Elkabes2, Semra Sökücü3, Cem Öcal4, Uğur Çevikbaş5, Günay Saner6
İstanbul Üniversitesi Çocuk Sağlığı Enstitüsü 1Pediatri Uzmanı, 6Pediatri Profesörü
İstanbul Tıp Fakültesi 2Pediatri Uzmanı, 3Pediatri Profesörü, 4Pediatri Araştırma Görevlisi, 5Patoloji Profesörü
Sixty-five children with a diagnosis of H. pylori (Hp) infection based on rapid urease test and histological examination were evaluated in terms of efficacy and theraupetic cost of omeprazole versus ranitidine. Children were assigned to receive either omeprazole (1-3 mg/kg/day) (OKM-group) or ranitidine (4-6 mg/kg/day) (RKM-group) together with clarithromycin (15 mg/kg/day) + metronidazole (20 mg/kg/day). Hp status was checked four weeks after completion of therapy by rapid urease test and histological examination obtained by repeat endoscopy. Treatment side effects were similar in the OKM-group (n=24) and RKM-group (n=41). Hp eradication rates were 91.7% and 85.4%, respectively (p>0.05). Our study suggests that no statistical difference between OKM therapy and RKM therapy exists in terms of efficacy and side effects in children. Anahtar Kelimeler : Helicobacter pylori, çocuk, tedavi, omeprazol, ranitidin, Helicobacter pylori, child, treatment, omeprazole, ranitidine
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