A 10 year-old girl was admitted to our hospital with five-day history of fever, bilateral neck swelling, and dyspnea. The patients symptoms suggested nasopharyngeal diphtheria and she was administered penicilin and, antitoxin immediately. Nevertheless myocarditis, syncope, neuropathy and hepatitis developed after two-week hospitalization. The patient was therefore administered carnitine, dopamine, dobutamine and immunglobulin. After hospitalization for 52 days, the patient was discharged with minimal hemiparesis. The remaining of symptoms resolved on follow-up. In this article we report a patient with diphtheria and review the literature. Anahtar Kelimeler : difteri, çoklu sistem tutulumu, myokardit, nöropati, hepatit, diphtheria, multiple system damage, myocarditis, neuropathy, hepatitis