Çocuk Sağlığı ve Hastalıkları Dergisi 2002 , Vol 45 , Num 3
The results of interferon alpha treatment of chronic hepatitis B infection in children
Mukaddes Kalyoncu1, Embiya Dilber1, Nilgün Yarış1, Ayşenur Ökten2
Karadeniz Teknik Üniversitesi Tıp Fakültesi 1Pediatri Yardımcı Doçenti, 2Pediatri Profesörü Chronic hepatitis B infection has a high risk concerning morbidity and mortality. Cirrhosis and hepatocellular carcinoma are the most important complications. Interferon alpha reduces these complications and mortality. In this paper, we aimed to evaluate epidemiological characteristics and response to six-month interferon alpha treatment (5 MU/m2, three times a week by subcutaneous injections) in children with chronic hepatitis B infection. A retrospective analysis of 28 cases admitted to our department were performed. Children tolerated the therapy well. Response to therapy was found in 32% of cases. Nonresponders had a histologically low hepatic activity index, low serum transaminase levels and high levels of hepatitis B virus DNA. We suggest that these patients must be treated with a higher dosage or that treatment must be of longer. Anahtar Kelimeler : kronik hepatit B enfeksiyonu, interferon-alfa, chronic hepatitis B, interferon alpha
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