Airway obstruction and feeding difficulties are the major issues in patients with Pierre-Robin sequence. Managing airway problems is challenging for both pediatricians and plastic and reconstructive surgeons. The main causes of airway obstruction are micrognathia and glossoptosis. Numerous therapeutic maneuvers have been used to stabilize the upper airway in these patients, such as prone positioning, tracheotomy and tongue-lip adhesions. However, high complication rates, long duration of hospitalization, ineffective airway management, and feeding difficulties are the disadvantages of these techniques. Mandibular distraction osteogenesis is an effective treatment to avoid tracheotomy and provide effective feeding in carefully selected Pierre-Robin sequence neonates. Here, we present a neonate with micrognathia and glossoptosis, who was treated with mandibular distraction, and we aimed to discuss the treatment modalities for airway management in patients with Pierre-Robin sequence. Anahtar Kelimeler : Pierre-Robin sekansı, distraksiyon osteogenezi.