Çocuk Sağlığı ve Hastalıkları Dergisi 2011 , Vol 54 , Num 4
The use of long-term intravenous atropine in organophosphate poisoning: experience of two patients
*Mustafa Taşkesen, Ayfer Gözü Pirinççioğlu, Hülya Üzel, Osman İyi
Dicle Üniversitesi Tıp Fakültesi ¹Pediatri Yardımcı Doçenti, ²Pediatri Araştırma Görevlisi Taşkesen M, Pirinççioğlu AG, Üzel H, İyi O. (Departments of Pediatrics, Dicle University Faculty of Medicine, Diyarbakır, Turkey). The use of long-term intravenous atropine in organophosphate poisoning: experience of two patients. Çocuk Sağlığı ve Hastalıkları Dergisi 2011; 54: 216-219.

Organophosphates cause irreversible inhibition of the cholinesterase enzyme in the nervous system. Organophosphate poisoning may lead to confusion, salivation, sweating, diarrhea, bradycardia, respiratory depression, and coma. This report involves two male siblings aged 5 and 8 years who were admitted to the emergency room after eating organophosphates-sprayed peaches from the garden. Their consciousness was lethargic and pupils were miotic; they had bradycardia, tachypnea and dyspnea with increased secretion and response to stimuli with agitation. In the follow-up, excessive respiratory tract secretions and respiratory failure were observed, so they were intubated for mechanical ventilation. Intermittent intravenous atropine and pralidoxime were given. Following development of increased bronchial secretions and worsening bronchospasm findings, intravenous infusion of atropine (0.02 to 0.08 mg/kg/h) was started. A significant decrease in secretion and bronchospasm was observed. Long-term intravenous atropine treatment should be considered in patients with organophosphate poisoning who are unresponsive to short-term and intermittent atropine. Anahtar Kelimeler : organofosfat, zehirlenme, atropin, intravenöz infüzyon.

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