Çocuk Sağlığı ve Hastalıkları Dergisi
2014 , Vol 57 , Num 1
Allergic inflammation
Hacettepe Üniversitesi Tıp Fakültesi 1Moleküler Biyoloji Doçenti, 2Pediatri Profesörü *İletişim: csackesen@yahoo.com
Allergic inflammation is characterized by immunoglobulin (Ig)E-dependent
activation of mucosal mast cells, which is orchestrated by an increased
number of activated CD4+ Th2 lymphocytes. The inflammatory process has
several common characteristics that are seen in different allergic diseases.
Allergic inflammation is due to the interaction between structural cells such
as smooth muscle cells, fibroblasts, epithelial and endothelial cells, and several
inflammatory cells, including mast cells, basophils, dendritic cells, T and B
lymphocytes, eosinophils, and neutrophils. These cells produce a wide range of
inflammatory mediators, including cytokines, chemokines and lipid mediators.
Recent studies have enabled the discovery of new cell subsets and mediators,
which interplay in allergic inflammation. In this review, the immediate and
late-phase of allergic response, newly described effector T cell subsets, and
natural killer T cells, and their roles in allergic diseases are described.
Anahtar Kelimeler :
allerji, enflamasyon, T hücre, dendritik hücre, mast hücresi.