Çocuk Sağlığı ve Hastalıkları Dergisi 2003 , Vol 46 , Num 4
Granulocyte-macrophage-colony-stimulating factor in the treatment of neonatal glossitis due to pseudomonas infection
Canan Aygün1, Evren Semizel2, Semra Çağlar Çetinkaya3, Murat Yurdakök4, Gülsevin Tekinalp4
Ondokuz Mayıs Üniversitesi 1Pediatri Yardımcı Doçenti, Uludağ Üniversitesi Tıp Fakültesi 2Pediatri Uzmanı
Hacettepe Üniversitesi Tıp Fakültesi 3Pediatri Uzmanı, 4Pediatri Profesörü
Granulocyte-macrophage-colony-stimulating factor (GM-CSF) not only influences the proliferation and differentiation of stem cells but also regulates other cells mediating inflammatory reactions and immune response. Accordingly, rhGM-CSF mouthwashes have been used for some years for the treatment of oral glossitis caused by radio- or chemotherapy. Based on these data we used topical rhGM-CSF in addition to parenteral antibiotic treatment in a preterm infant with glossitis due to Pseudomonas aeruginosa. We observed a quick healing of the tongue without any side effects. Anahtar Kelimeler : granülosit-makrofaj-koloni stimülan faktör, glossit, yenidoğan, granulocyte-macrophage-colony-stimulating factor, glossitis, newborn
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