Topical corticosteroids are one of the oldest and most frequently used treatments for dermatologic conditions. Corticosteroids are absorbed easily through the skin, and this may lead to a varying degree of suppression of the hypothalamic-pituitary-adrenal axis. Herein, we report a seven-month-old female infant with ichthyosis who developed iatrogenic Cushing's syndrome after diaper dermatitis treatment involving the extensive misuse of topical diflucortolone valerate prescribed by the physician. We also discuss the effects of topical steroids on the adrenal axis. The body surface area in children is so large in comparison to the body mass, and their skin is thin; hence, they may readily suffer the systemic side effects of the percutaneous absorption of corticosteroids. Awareness of the side effects is important when prescribing steroid-containing medication, especially during childhood.

Keywords: kortikosteroidler, iatrojenik Cushing sendromu, iktiyozis, süt çocukluğu.