Dubin-Johnson and Rotor syndromes are rare, benign, hereditary chronic disorders characterized by conjugated hyperbilirubinemia. In Dubin-Johnson syndrome, deposition of melanin-like pigment in otherwise normal liver cells and in some cases hepatomegaly and abdominal pain are observed. Both syndromes show no abnormality in other liver function tests, and patients with these syndromes are otherwise healthy. Differential diagnosis of these diseases must be considered in patients with slightly elevated conjugated hyperbilirubinemia and normal liver functions. Three cases of Dubin-Johnson and Rotor syndrome are reported herein, and the differential diagnosis is discussed.

Keywords: Sarılık, Dubin-Johnson sendromu, Rotor sendromu.