Kikuchi-Fujimoto disease (KFD) is characterized by fever and cervical lymphadenopathy (LAP). Some systemic signs and symptoms and laboratory findings can be noted. Definite diagnosis is made by excisional lymph node biopsy that reveals histiocytic necrotizing lymphadenitis. We present here an adolescent case of KFD and discuss signs and symptoms of the disease. A 14-year-old boy presented with fatigue and left-sided neck swelling beginning 3-4 days before. On exam, he had enlarged lymph nodes that were conglomerated, firm, non-tender and painless. He had increased atypical lymphocytes on blood smear, mildly elevated erythrocyte sedimentation rate and markedly elevated liver tests. Because of the persistence of symptoms and signs, the patient underwent excisional lymph node biopsy that revealed KFD. In the follow-up, fatigue disappeared spontaneously and elevated liver tests returned to normal. No recurrence was observed during the year after diagnosis.

Keywords: Kikuchi-Fujimoto disease, lymphadenopathy.