Sixty-five children with a diagnosis of H. pylori (Hp) infection based on rapid urease test and histological examination were evaluated in terms of efficacy and theraupetic cost of omeprazole versus ranitidine. Children were assigned to receive either omeprazole (1-3 mg/kg/day) (OKM-group) or ranitidine (4-6 mg/kg/day) (RKM-group) together with clarithromycin (15 mg/kg/day) + metronidazole (20 mg/kg/day). Hp status was checked four weeks after completion of therapy by rapid urease test and histological examination obtained by repeat endoscopy. Treatment side effects were similar in the OKM-group (n=24) and RKM-group (n=41). Hp eradication rates were 91.7% and 85.4%, respectively (p>0.05). Our study suggests that no statistical difference between OKM therapy and RKM therapy exists in terms of efficacy and side effects in children.

Keywords: Helicobacter pylori, çocuk, tedavi, omeprazol, ranitidin, child, treatment, omeprazole, ranitidine