Persistent cloaca and cloacal exstrophy are the rare congenital anomalies of the urogenital system and anorectum. The persistent cloaca is formed by the rectum, vagina, and urethra approaching a common channel, resulting in the opening of a single perineal region. It is characterized by the exstrophy of the urinary tract, genital organs, and intestines as a result of inadequate closure of the abdominal wall. In this article, a newborn with cloacal exstrophy and omphalocele, diagnosed in prenatal period, was presented and discussed in the light of recent literature data.

Keywords: persistent cloaca, cloacal exstrophy, omphalocele, anal atresia, newborn