Neonatal cholestasis is a condition that begins in the neonatal period due to intrahepatic and the extrahepatic causes. The objective of our study was to evaluate the ethiological factors, symptoms and physical examination findings, laboratory results and follow up results for cases with neonatal cholastasis and to compare this data with those of other studies. Neonatal cholestasis cases that were diagnosed between 2009-2014 in Neonatal Care Unit were included in this study. The diagnoses, physical examinations, clinical courses and the prognoses were retrospectively evaluated in two groups; younger than 32 weeks (Group 1) and older than 32 weeks (Group 2). 94 newborns were found to have neonatal cholestasis. Patients in Group 2 (n= 60) had earlier neonatal cholestasis (p=0.001). The most common complaints of the patients and/or physical examination findings were jaundice. The most common etiologic factors involved in the etiology of neonatal cholestasis were TPN associated cholestasis (n= 21). No etiology was defiend in 13 patients. It was observed that 33 (35%) of the patients died during the follow-up. We consider that the early diagnosis is important; during the search of the etiological cause, the features such as the gestational age and the birth weight of the patient should be taken into consideration and we also consider that when the extrahepatic causes are relevant, the surgical treatment should not be delayed.

Keywords: neonatal cholestasis, jaundice, newborn