The maturation of digestion and absorption functions of small bowel and migration and proliferation of epithelial cells continue after birth. It was noticed via animal experiments that steroids had an important role in this process. This study had aimed to search the role of the circadian rhythm of cortisol which is known to have an important role of bowel development in infantile colic pathogenesis. Patients which applied for well child examination to our clinic and diagnosed as infantile colic according to Wessel criteria were enrolled in the trial. While it was determined that the saliva samples, which were collected in the morning at the time of diagnosis and at the sixth month of both groups, were higher than in evening samples. Statistically, there was no difference between the groups. It was determined that, although not statistically meaningful, rate of changes between morning and evening cortisol levels of the infantile colic group were less than the control group. We did not find the role of circadian rhythm of the cortisol as the etiopathogenesis of the infantil colic.

Keywords: infantile colic, cortisol, circadian rhythm